Silent but Deadly, and Beneficial? – Natural Killer Cells Natural Killer (NK) cells play a major role in targeting and killing both tumor cells and virally infected cells in the body. Although they play a very similar role to cytotoxic T cells, these cells comprise an important component of the host’s innate immune system.  Most […]

In pharmaceutical drug development, quality is critical.  The FDA relies on quality driven documents to make decisions on the safety and effectiveness of regulated products and the approval of those products.  While Quality Assurance (QA) is a clear regulatory requirement in some instances (i.e., studies required to be compliant with Good Laboratory Practices), it can […]

If you are looking to incorporate flow cytometry into your study or clinical trial, ensuring that precise and uniform data is generated by contract flow labs can seem difficult, or even overwhelming.  In fact, a study conducted by Maecker et al. 2005 revealed that in a protocol conducted across 15 different laboratories, the inter-laboratory coefficient […]

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Controls are a vital part of any rigorous scientific process. Any experiment worth its peer-reviewed credentials requires controls to verify these data are valid, and that variables outside of the parameter of interest are not confounding the results in any way. In the rapidly-expanding field of flow cytometry, it is no different.  However, finding the […]

For typical flow cytometry assays, specimens are processed separately with the antibody panels to enumerate lymphocyte subsets of interest, yielding a sample by sample processing for each individual being tested. Although several hundred samples can be processed using this approach, what if there were methods to optimize efficiency of the flow cytometry testing, depending on […]

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Not everyone can say that they work on a project that has the potential to benefit millions of patients.  But we do. e work for the UW Medicine Heart Regeneration Program (HRP) within the University of Washington’s Institute for Stem Cell and Regenerative Medicine.  HRP scientists have expertise in stem cell biology, cardiovascular medicine, Good […]