The Natural Killer Cell Cytotoxicity Assay Natural killer cells (NK cells) are a subset of blood lymphocytes that play an essential role in immunosurveillance and the innate immune response.   As a first line of defense, NK cells specifically recognize virally infected and malignantly transformed cells and target them for killing and removal.   And they work […]

Since the first flow cytometers became commercially available 40+ years ago, the field of flow cytometry has grown in leaps and bounds.   The earliest flow cytometers could measure 1-2 cellular parameters, while today, we take for granted that flow cytometers allow us routinely measure up to 20+ fluorescent parameters simultaneously.    Modern flow cytometers are also […]

Silent but Deadly, and Beneficial? – Natural Killer Cells Natural Killer (NK) cells play a major role in targeting and killing both tumor cells and virally infected cells in the body. Although they play a very similar role to cytotoxic T cells, these cells comprise an important component of the host’s innate immune system.  Most […]

In pharmaceutical drug development, quality is critical.  The FDA relies on quality driven documents to make decisions on the safety and effectiveness of regulated products and the approval of those products.  While Quality Assurance (QA) is a clear regulatory requirement in some instances (i.e., studies required to be compliant with Good Laboratory Practices), it can […]

If you are looking to incorporate flow cytometry into your study or clinical trial, ensuring that precise and uniform data is generated by contract flow labs can seem difficult, or even overwhelming.  In fact, a study conducted by Maecker et al. 2005 revealed that in a protocol conducted across 15 different laboratories, the inter-laboratory coefficient […]

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Controls are a vital part of any rigorous scientific process. Any experiment worth its peer-reviewed credentials requires controls to verify these data are valid, and that variables outside of the parameter of interest are not confounding the results in any way. In the rapidly-expanding field of flow cytometry, it is no different.  However, finding the […]